DNA replication factor Cdt1 is a protein that in humans is encoded by the CDT1 gene.
The protein encoded by this gene is a key licensing factor which, along with the protein Cdc6, functions to license DNA by forming the pre-replication complex (pre-RC). Its activity during the cell cycle is tightly regulated by its association with the protein geminin, which both inhibits Cdt1 activity during S phase in order to prevent re-replication of DNA and prevents it from ubiquitination and subsequent proteolysis.
Read more about DNA Replication Factor CDT1: Orthologs, Interactions
Famous quotes containing the words dna and/or factor:
“Here [in London, history] ... seemed the very fabric of things, as if the city were a single growth of stone and brick, uncounted strata of message and meaning, age upon age, generated over the centuries to the dictates of some now all-but-unreadable DNA of commerce and empire.”
—William Gibson (b. 1948)
“You factor in racism as a reality and you keep moving.”
—Jewell Jackson McCabe (b. 1945)