Global Response To DNA Damage
Cells exposed to ionizing radiation, ultraviolet light or chemicals are prone to acquire multiple sites of bulky DNA lesions and double-strand breaks. Moreover, DNA damaging agents can damage other biomolecules such as proteins, carbohydrates, lipids, and RNA. The accumulation of damage, to be specific, double-strand breaks or adducts stalling the replication forks, are among known stimulation signals for a global response to DNA damage. The global response to damage is an act directed toward the cells' own preservation and triggers multiple pathways of macromolecular repair, lesion bypass, tolerance, or apoptosis. The common features of global response are induction of multiple genes, cell cycle arrest, and inhibition of cell division.
Read more about this topic: DNA Repair
Famous quotes containing the words global, response, dna and/or damage:
“Ours is a brand—new world of allatonceness. “Time” has ceased, “space” has vanished. We now live in a global village ... a simultaneous happening.”
—Marshall McLuhan (1911–1980)
“Love is the victim’s response to the rapist.”
—Ti-Grace Atkinson (b. 1938?)
“Here [in London, history] ... seemed the very fabric of things, as if the city were a single growth of stone and brick, uncounted strata of message and meaning, age upon age, generated over the centuries to the dictates of some now all-but-unreadable DNA of commerce and empire.”
—William Gibson (b. 1948)
“I came to explore the wreck.
The words are purposes.
The words are maps.
I came to see the damage that was done
and the treasures that prevail.”
—Adrienne Rich (b. 1929)