Spontaneous
Spontaneous or accidental DNA fragmentation is fragmentation that gradually accumulates in a cell. It can be measured by e.g. Comet assay.
The degree of DNA fragmentation can predict outcomes for in vitro fertilization (IVF) and its expansion intracytoplasmic sperm injection (ICSI). The sperm chromatin dispersion test (SCD) and TUNEL assay are both effective in detecting sperm DNA damage. Using bright-field microscopy, the SCD test appears to be more sensitive than the TUNEL assay.
Its main units of measurement is DNA fragmentation index (DFI). A DFI of 20% or more significantly reduces the success rates after ICSI.
Read more about this topic: DNA Fragmentation
Famous quotes containing the word spontaneous:
“What is saved in the cinema when it achieves art is a spontaneous continuity with all mankind. It is not an art of the princes or the bourgeoisie. It is popular and vagrant. In the sky of the cinema people learn what they might have been and discover what belongs to them apart from their single lives.”
—John Berger (b. 1926)
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—David Elkind (20th century)
“If an educational act is to be efficacious, it will be only that one which tends to help toward the complete unfolding of life. To be thus helpful it is necessary rigorously to avoid the arrest of spontaneous movements and the imposition of arbitrary tasks.”
—Maria Montessori (1870–1952)