Dlc1

DLC1

Identifiers Symbols DLC1; ARHGAP7; HP; STARD12; p122-RhoGAP External IDs OMIM: 604258 HomoloGene: 4442 GeneCards: DLC1 Gene

Gene Ontology
Molecular function	• Rho GTPase activator activity • protein binding • vinculin binding • Rac GTPase activator activity • SH2 domain binding • phospholipase binding
Cellular component	• stress fiber • nucleus • cytoplasm • cytosol • actin filament • caveola • focal adhesion
Biological process	• neural tube closure • heart morphogenesis • induction of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process • activation of phospholipase C activity • small GTPase mediated signal transduction • negative regulation of cell proliferation • regulation of cell shape • hindbrain morphogenesis • actin cytoskeleton organization • negative regulation of cell migration • forebrain development • cellular response to insulin stimulus • regulation of actin cytoskeleton organization • negative regulation of Rho protein signal transduction • positive regulation of protein dephosphorylation • focal adhesion assembly • regulation of small GTPase mediated signal transduction • negative regulation of stress fiber assembly
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10395 50768 Ensembl ENSG00000164741 ENSMUSG00000031523 UniProt Q96QB1 Q9R0Z9 RefSeq (mRNA) NM_001164271 NM_001194940 RefSeq (protein) NP_001157743 NP_001181869 Location (UCSC) Chr 8:
12.94 – 13.37 Mb Chr 8:
36.57 – 36.95 Mb PubMed search

Deleted in Liver Cancer 1 also known as DLC1 and StAR-related lipid transfer protein 12 (STARD12) is a protein which in humans is encoded by the DLC1 gene.