D. palustris is a widespread species that grows in scattered populations throughout eastern North America, from Nova Scotia west to North Dakota and Oklahoma, and south to Florida. D. occidentalis grows in a several counties in the San Francisco Bay area of California. D. mexicana was described in 1995 from one population in northeastern Mexico. In 2008, a fourth species, D. decipiens, was described from several populations in Kansas and Arkansas, at the southwestern limits of the range of D. palustris.
Dirca palustris is occasionally cultivated, although its slow growth seems to prevent its widespread use in horticulture. The shrub is often difficult to recognize because the flowers are small (less than one cm), displayed for only a short period in the early spring, and may be a nondescript greenish-yellow. In the central part of its range, "D. palustris" is often found growing with the much more frequent Spicebush, which also has small yellow flowers that appear before the leaves at a similar time.
Although it is listed as poisonous in some publications because its stems and leaves contain calcium oxalate crystals, its toxicity is uncertain and may be low. Likewise, the berries may have narcotic properties, although this claim remains unsubstantiated.