Desnoyers is a surname, and may refer to:
- Adam Desnoyers, an American author.
- Auguste Gaspard Louis Desnoyers (1800-1887), a French engraver.
- Daniel Desnoyers, a Canadian radio host and DJ.
- Jules Desnoyers (1779-1857), a French geologist and archaeologist.
- Luc Desnoyers (born 1950), a Canadian politician.
- Peter J. Desnoyers (1772-1846), a Detroit silversmith and businessman.
- Peter Desnoyers (1800-1880), a Detroit businessman and politician.