Signs and Symptoms
DRPLA can be juvenile-onset (< 20 years), early adult-onset (20–40 years), or late adult-onset (> 40 years). Late adult-onset DRPLA is characterized by ataxia, choreoathetosis and dementia. Early adult-onset DRPLA also includes seizures and myoclonus. Juvenile-onset DRPLA presents with ataxia and symptoms consistent with progressive myoclonus epilepsy (myoclonus, multiple seizure types and dementia). Other symptoms that have been described include cervical dystonia, corneal endothelial degeneration autism, and surgery-resistant obstructive sleep apnea.
Read more about this topic: Dentatorubral-pallidoluysian Atrophy
Famous quotes containing the words signs and, signs and/or symptoms:
“Time has an undertaking establishment on every block and drives his coffin nails faster than the steam riveters rivet or the stenographers type or the tickers tick out fours and eights and dollar signs and ciphers.”
—John Dos Passos (1896–1970)
“The family is in flux, and signs of trouble are widespread. Expectations remain high. But realities are disturbing.”
—Robert Neelly Bellah (20th century)
“Social movements are at once the symptoms and the instruments of progress. Ignore them and statesmanship is irrelevant; fail to use them and it is weak.”
—Walter Lippmann (1889–1974)