Effects On Human Health
Potential mechanisms of action on humans are genotoxicity and endocrine disruption. DDT can be directly genotoxic, but may also induce enzymes to produce other genotoxic intermediates and DNA adducts. It is an endocrine disruptor; The DDT metabolite DDE acts as an antiandrogen (but not as an estrogen). p,p'-DDT, DDT's main component, has little or no androgenic or estrogenic activity. Minor component o,p'-DDT has weak estrogenic activity.
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