As A Surname
- Billy Darnell (1926-2007), American professional wrestler
- Bruce Darnell, American model and choreographer
- Eric Darnell, American film director
- Erik Darnell, American stock car racing driver
- Gary Darnell, former College football coach
- James E. Darnell, American biologist
- Jean Darnell (1889-1961), American silent film actress
- Larry Darnell (1928-1983), American singer
- Linda Darnell (1923-1965), American film actress
- Mike Darnell, American television executive
- Nicholas Henry Darnell (1807-1885), American politician
- Regna Darnell, Canadian anthropologist
- Riley Darnell, Secretary of State for the state of Tennessee
- Ryan Darnell, Irish YouTuber and Voice Actor
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