CYP2E1 Ligands
Following is a table of selected substrates, inducers and inhibitors of CYP2E1. Where classes of agents are listed, there may be exceptions within the class.
Selected inducers, inhibitors and substrates of CYP2E1
Substrates |
Inhibitors |
Inducers |
- anaesthetics:
- halothane
- enflurane
- isoflurane
- methoxyflurane
- sevoflurane
- paracetamol (acetaminophen) - used as analgesic, antipyretic - toxication by CYP2E1
- ethanol (psychoactive)
- Industrial potentially toxic substances
- aniline
- benzene
- dimethylformamide
- theophylline (stimulant)
- chlorzoxazone (muscle relaxant)
|
- diethyldithiocarbamate (in cancer)
- disulfiram (in alcoholism)
|
- ethanol (psychoactive)
- isoniazid (in tuberculosis)
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