CYP2E1 - CYP2E1 Ligands

CYP2E1 Ligands

Following is a table of selected substrates, inducers and inhibitors of CYP2E1. Where classes of agents are listed, there may be exceptions within the class.

Selected inducers, inhibitors and substrates of CYP2E1
Substrates Inhibitors Inducers
  • anaesthetics:
    • halothane
    • enflurane
    • isoflurane
    • methoxyflurane
    • sevoflurane
  • paracetamol (acetaminophen) - used as analgesic, antipyretic - toxication by CYP2E1
  • ethanol (psychoactive)
  • Industrial potentially toxic substances
    • aniline
    • benzene
    • dimethylformamide
  • theophylline (stimulant)
  • chlorzoxazone (muscle relaxant)
  • diethyldithiocarbamate (in cancer)
  • disulfiram (in alcoholism)
  • ethanol (psychoactive)
  • isoniazid (in tuberculosis)

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