Genetic Basis of Variability
The genetic basis for extensive and poor metaboliser variability is the CYP2D6 allele, located on chromosome 22. Subjects possessing certain allelic variants will show normal, decreased, or no CYP2D6 function, depending on the allele.
| CYP2D6 allele and enzyme activity | |
| Allele | CYP2D6 activity |
| CYP2D6*1 | normal |
| CYP2D6*2 | increased |
| CYP2D6*3 | none |
| CYP2D6*4 | none |
| CYP2D6*5 | none |
| CYP2D6*9 | decreased |
| CYP2D6*10 | decreased |
| CYP2D6*17 | decreased |
Read more about this topic: CYP2D6
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