CYP2C8 Ligands
Following is a table of selected substrates, inducers and inhibitors of 2C8.
Inhibitors of CYP2C8 can be classified by their potency, such as:
- Strong inhibitor being one that causes at least a five-fold increase in the plasma AUC values, or more than 80% decrease in clearance.
- Moderate inhibitor being one that causes at least a two-fold increase in the plasma AUC values, or 50-80% decrease in clearance.
- Weak inhibitor being one that causes at least a 1.25-fold but less than two-fold increase in the plasma AUC values, or 20-50% decrease in clearance.
Substrates | Inhibitors | Inducers |
---|---|---|
|
Strong:
Moderate
Unspecified potency
|
Where classes of agents are listed, there may be exceptions within the class. Read more about this topic: CYP2C8 |