Research
A formulation of cyclobenzaprine is being developed for the management of fibromyalgia by Tonix Pharmaceuticals. This formulation contains a very low dose (VLD) of cyclobenzaprine as compared to currently marketed products. By targeting sleep quality, VLD cyclobenzaprine is designed to address the non-restorative sleep feature of fibromyalgia. In a randomized, double-blind, placebo-controlled Phase II clinical study in 36 patients, VLD-cyclobenzaprine given at bedtime was shown to significantly improve core fibromyalgia symptoms and was well tolerated. Reported clinical benefits include reductions in pain, fatigue, and depression.
Read more about this topic: Cyclobenzaprine
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