Cyclin D1

Cyclin D1

Identifiers Symbols CCND1; BCL1; D11S287E; PRAD1; U21B31 External IDs OMIM: 168461 MGI: 88313 HomoloGene: 1334 ChEMBL: 3610 GeneCards: CCND1 Gene

Gene Ontology
Molecular function	• protein kinase activity • protein binding • cyclin-dependent protein kinase regulator activity • enzyme binding • protein kinase binding
Cellular component	• cyclin-dependent protein kinase holoenzyme complex • intracellular • nucleus • nucleoplasm • cytosol • membrane
Biological process	• G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • mitotic cell cycle • re-entry into mitotic cell cycle • liver development • positive regulation of protein phosphorylation • response to DNA damage stimulus • lactation • response to iron ion • response to X-ray • response to organic nitrogen • negative regulation of Wnt receptor signaling pathway • negative regulation of epithelial cell differentiation • endoplasmic reticulum unfolded protein response • organ regeneration • mitotic cell cycle G1/S transition DNA damage checkpoint • response to magnesium ion • response to vitamin E • Leydig cell differentiation • mammary gland epithelial cell proliferation • positive regulation of mammary gland epithelial cell proliferation • response to drug • response to estrogen stimulus • fat cell differentiation • response to ethanol • positive regulation of cyclin-dependent protein kinase activity • cell division • response to corticosterone stimulus • response to calcium ion • canonical Wnt receptor signaling pathway • mammary gland alveolus development • response to UV-A
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 595 12443 Ensembl ENSG00000110092 ENSMUSG00000070348 UniProt P24385 P25322 RefSeq (mRNA) NM_053056.2 NM_007631.2 RefSeq (protein) NP_444284.1 NP_031657.1 Location (UCSC) Chr 11:
69.46 – 69.47 Mb Chr 7:
144.93 – 144.94 Mb PubMed search

G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene.

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma.