Cyclin - Domain Structure

Domain Structure

Cyclins are generally very different from each other in primary structure, or amino acid sequence. The similarity between members of the cyclin family are similar in the 100 amino acids that make up the cyclin box. Cyclins contain two domains of similar all-α fold, the first located at the N-terminus and the second at the C-terminus. All cyclins are believed to contain a similar tertiary structure of two compact domains of 5 α helices. The first of which is the conserved cyclin box, outside of which cyclins are divergent. For example, the amino-terminal regions of S and M cyclins contain short destruction-box motifs that target these proteins for proteolysis in mitosis.

Cyclin, N-terminal domain
Structure of bovine cyclin A.
Identifiers
Symbol Cyclin_N
Pfam PF00134
Pfam clan CL0065
InterPro IPR006671
PROSITE PDOC00264
SCOP 1vin
SUPERFAMILY 1vin
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
Cyclin, C-terminal domain
Structure of CDK2-cyclin A/indirubin-5-sulphonate.
Identifiers
Symbol Cyclin_C
Pfam PF02984
Pfam clan CL0065
InterPro IPR004367
PROSITE PDOC00264
SCOP 1vin
SUPERFAMILY 1vin
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
K cyclin, C terminal
structure of a p18(ink4c)-cdk6-k-cyclin ternary complex
Identifiers
Symbol K-cyclin_vir_C
Pfam PF09080
InterPro IPR015164
SCOP 1g3n
SUPERFAMILY 1g3n
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

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