Cyclin-dependent Kinase 6

Cyclin-dependent Kinase 6

Identifiers Symbols CDK6; PLSTIRE External IDs OMIM: 603368 MGI: 1277162 HomoloGene: 963 ChEMBL: 2508 GeneCards: CDK6 Gene EC number 2.7.11.22

Gene Ontology
Molecular function	• cyclin-dependent protein kinase activity • protein binding • ATP binding • cyclin binding
Cellular component	• cyclin-dependent protein kinase holoenzyme complex • ruffle • nucleus • cytoplasm • cytosol
Biological process	• G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • mitotic cell cycle • positive regulation of cell-matrix adhesion • hematopoietic progenitor cell differentiation • type B pancreatic cell development • protein phosphorylation • cell cycle arrest • Notch signaling pathway • negative regulation of cell proliferation • response to virus • regulation of gene expression • positive regulation of gene expression • astrocyte development • dentate gyrus development • lateral ventricle development • T cell differentiation in thymus • gliogenesis • cell dedifferentiation • negative regulation of cell differentiation • negative regulation of myeloid cell differentiation • regulation of erythrocyte differentiation • negative regulation of osteoblast differentiation • negative regulation of cell cycle • positive regulation of fibroblast proliferation • generation of neurons • negative regulation of epithelial cell proliferation • cell division • hematopoietic stem cell differentiation • regulation of cell motility • negative regulation of cellular senescence
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1021 12571 Ensembl ENSG00000105810 ENSMUSG00000040274 UniProt Q00534 Q64261 RefSeq (mRNA) NM_001145306.1 NM_009873.2 RefSeq (protein) NP_001138778.1 NP_034003.1 Location (UCSC) Chr 7:
92.23 – 92.47 Mb Chr 5:
3.34 – 3.52 Mb PubMed search

Cell division protein kinase 6 is an enzyme that in humans is encoded by the CDK6 gene.

It is regulated by Cyclin D.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.