Degradation
Numerous cyclic nucleotide phosphodiesterases (PDE) can degrade cGMP by hydrolyzing cGMP into 5'-GMP. PDE 5, -6 and -9 are cGMP-specific while PDE1, -2, -3, -10 and -11 can hydrolyse both cAMP and cGMP.
Phosphodiesterase inhibitors prevent the degradation of cGMP, thereby enhancing and/or prolonging its effects. For example, Sildenafil (Viagra) and similar drugs enhance the vasodilatory effects of cGMP within the corpus cavernosum by inhibiting PDE 5 (or PDE V). This is used as a treatment for erectile dysfunction. However, the drug can inhibit PDE6 in retina (albeit with less affinity than PDE5). This has been shown to result in loss of visual sensitivity but is unlikely to impair common visual tasks, except under conditions of reduced visibility when objects are already near visual threshold. This effect is largely avoided by other PDE5 inhibitors, such as tadalafil.
Read more about this topic: Cyclic Guanosine Monophosphate
Famous quotes containing the word degradation:
“The three great problems of this century, the degradation of man in the proletariat, the subjection of women through hunger, the atrophy of the child by darkness.”
—Victor Hugo (1802–1885)
“Such poverty as we have today in all our great cities degrades the poor, and infects with its degradation the whole neighborhood in which they live. And whatever can degrade a neighborhood can degrade a country and a continent and finally the whole civilized world, which is only a large neighborhood.”
—George Bernard Shaw (1856–1950)
“It was the most ungrateful and unjust act ever perpetrated by a republic upon a class of citizens who had worked and sacrificed and suffered as did the women of this nation in the struggle of the Civil War only to be rewarded at its close by such unspeakable degradation as to be reduced to the plane of subjects to enfranchised slaves.”
—Anna Howard Shaw (1847–1919)