Cruzan can mean:
- The alternate spelling of Crucian, a native of St. Croix, U.S. Virgin Islands, or the native dialect spoken on that island, also known as Virgin Islands Creole.
- Cruzan Rum, a rum produced on St. Croix, U.S. Virgin Islands.
- Nancy Cruzan, a key figure in the right-to-die movement.
- Cruzan Amphitheatre, a 19,000-seat open-air music venue in West Palm Beach, Florida.