Embryology and Anatomy
The corneal endothelium is embryologically derived from the neural crest. The postnatal total endothelial cellularity of the cornea (approximately 300,000 cells per cornea) is achieved as early as the second trimester of gestation. Thereafter the endothelial cell density (but not the absolute number of cells) rapidly declines, as the fetal cornea grows in surface area, achieving a final adult density of approximately 2400 - 3200 cells/mm². The number of endothelial cells in the fully developed cornea decreases with age up until early adulthood, stabilizing around 50 years of age.
The normal corneal endothelium is a single layer of uniformly sized cells with a predominantly hexagonal shape. This honeycomb tiling scheme yields the greatest efficiency, in terms of total perimeter, of packing the posterior corneal surface with cells of a given area. The corneal endothelium is attached to the rest of the cornea through Descemet's membrane, which is an acellular layer composed mostly of collagen.
Read more about this topic: Corneal Endothelium
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“Man is a shrewd inventor, and is ever taking the hint of a new machine from his own structure, adapting some secret of his own anatomy in iron, wood, and leather, to some required function in the work of the world.”
—Ralph Waldo Emerson (1803–1882)