Constantine Palaiologos may refer to:
- Constantine Palaiologos (half-brother of Michael VIII) (d.1271), half-brother of Michael VIII Palaiologos and grandfather of Theodora Smilets of Bulgaria
- Constantine Palaiologos (son of Michael VIII) (1261–1306), sebastokrator, son of Michael VIII Palaiologos
- Constantine Palaiologos (son of Andronikos II) (fl. 1292–1320s), despotes, son of Andronikos II Palaiologos
- Constantine XI Palaiologos (1405–1453), last ruler of the Byzantine Empire in 1449–1453