Central Dogma
The difference in selector gene activity not only establishes two compartments, but also leads to the formation of a boundary between these two that serves as a source of morphogen gradients. In the central dogma of compartments, first, morphogen gradients position founder compartment cells. Then, active/inactive selector genes give a unique genetic identity to cells within a compartment, instructing their fate and their interactions with the neighboring compartment. Finally, border cells, established by short-range signaling from one compartment to its neighboring compartment emit long-range signals that spread to both compartments to regulate the growth and pattering of the entire tissue.
Read more about this topic: Compartment (development)
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