Computing
- CMS-2 (programming language), used by the United States Navy
- Client Music Synthesis, a technology to transfer music files with extremely high data compression ratio
- Code Morphing Software, a technology used by Transmeta
- Color management system, a system for computers to control the representation of colors
- Construction and management simulation, a type of simulation video game
- Contact management system, an integrated office solution to record relationships and interactions with customers and suppliers
- Content management system, a system for managing content and providing it in various formats
- Computer Management System, a Burroughs/Unisys small-computer operating system
- Conversational Monitor System, previously Cambridge Monitor System, an IBM mainframe operating system
- Course management system, software that facilitates e-learning or computer learning
- Cryptographic Message Syntax, a cryptographic standard
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