Drug Interactions
Clomipramine shows a number of clinical significant interactions, either due to central depressant or stimulant activity of the other drug or due to interference of the other drug with the metabolization and elimination of clomipramine or vice versa. Some examples are:
- MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine): severe reactions including central excitation, hypertensive crisis, bizarre behaviour, psychosis, seizures, coma and death are possible. Serotonin syndrome is likely.
- Central stimulants: Potentially dangerous central excitation with agitation and anxiety may be encountered.
- SSRI type antidepressants (e.g. fluoxetine): Side effects of clomipramine are increased. May cause Serotonin syndrome.
- Drugs with central depressant activity (tranquilizers, alcohol, narcotics): Increased central depression (dizziness, drowsiness etc.) is frequently noted.
- Antihypertensive drugs: The risk of hypotension, collapse, and tachycardia is increased.
- Interactions with OTC medications against colds and sleeping aids with diphenhydramine, doxylamine and St. John's wort may occur.
Read more about this topic: Clomipramine
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