Clomipramine - Contraindications

Contraindications

• Concomitant therapy with an (irreversible) MAO inhibitor (e.g. tranylcypromine, phenelzine)
• Acute intoxication with central depressants (alcohol, psychoactive drugs, narcotics)
• States of confusion (caution), absolutely contraindicated in patients with coma and delirium tremens
• Patients with severe agitation or anxiety (give sedative drugs concomitantly)
• Hypersensitivity/allergy against clomipramine or other related tricyclic compounds
• Hypertrophy of the prostate with or without urine retention (difficulty in urinating)
• Pre-existing closed angle glaucoma
• Epilepsy and other conditions which lower the seizure threshold (alcohol withdrawal, active brain tumors)
• Serious liver disease (elimination is decreased), if clomipramine is given consider dose reduction
• Serious kidney disease (elimination is decreased), if clomipramine is given consider dose reduction
• Severe hypotension, shock, serious cardiovascular dysfunction (postinfarctous states, heart insufficience, arrhythmias), avoid high oral doses or injections/infusions
• Pre-existing bone marrow depression (leukopenia, thrombocytopenia, anemia, pancytopenia), can be worsened by clomipramine
• Hyperthyroidism (overfunction of the thyroid gland) makes the patient more sensitive to side effects of clomipramine. Cautious doses should be used and the overfunction should be treated.
• Caution should be exerted when treating pediatric patients under 18 years of age