Computers
- .cl, internet country code top-level domain for Chile
- CAS Latency, a measure used in computer memory
- Combinatory logic, in computer science
- Common Lisp, a programming language
- Common logic, a framework for a family of logic languages
- AS/400 Control Language, a scripting language for the IBM AS/400 midrange platform
- cl.exe is the command-line C/C++ compiler for Microsoft Visual C++
- CL register, the low byte of an X86 16-bit CX register
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