Langerhans Cells and HIV Transmission
Langerhans cells are part of the human immune system. Three studies identified high concentrations of Langerhans and other "HIV target" cells in the foreskin and Szabo and Short suggested that the Langerhans cells in the foreskin may provide an entry point for viral infection. McCoombe, Cameron, and Short also found that the keratin is thinnest on the foreskin and frenulum. Van Howe, Cold and Storms criticised Szabo and Short's suggestion as "pure speculation". Fleiss, Hodges and Van Howe had previously stated a belief that the prepuce has an immunological function. Waskett criticised their specific hypothesis on technical grounds. A study published in 2007 by de Witte and others said that langerin, produced by Langerhans cells, is a natural barrier to HIV-1 transmission by Langerhans cells.
Dowsett (2007) questioned why it was just males that were being encouraged to circumcise: "Langerhans cells occur in the clitoris, the labia and in other parts of both male and female genitals, and no one is talking of removing these in the name of HIV prevention."
Read more about this topic: Circumcision And HIV
Famous quotes containing the word cells:
“They are sworn enemies of lyric poetry.
In prison they accompany the jailer,
Enter cells to hear confessions.
Their short-end comes down
When you least expect it.”
—Charles Simic (b. 1938)