Chronic Granulomatous Disease - Symptoms

Symptoms

Classically, patients with chronic granulomatous disease will suffer from recurrent bouts of infection due to the decreased capacity of their immune system to fight off disease-causing organisms. The recurrent infections they acquire are specific and are, in decreasing order of frequency:

  • pneumonia
  • abscesses of the skin, tissues, and organs
  • suppurative arthritis
  • osteomyelitis
  • bacteremia/fungemia
  • superficial skin infections such as cellulitis or impetigo

Most people with CGD are diagnosed in childhood, usually before age 5. Early diagnosis is important since these people can be placed on antibiotics to ward off infections before they occur.

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