Christopher Sykes may refer to:
- Christopher Sykes (MP) (1831–1898), Member of Parliament and friend of Edward VII as Prince of Wales
- Christopher Sykes (author) (1907–1986), English author, best known for his biography of Evelyn Waugh
- Sir Christopher Sykes, 2nd Baronet (1749–1801), Member of Parliament for Beverley, 1784–1790