CHP (gene)

CHP (gene)

Identifiers Symbols CHP1; CHP; SLC9A1BP; Sid470p; p22; p24 External IDs OMIM: 606988 MGI: 1927185 HomoloGene: 5235 GeneCards: CHP1 Gene

Gene Ontology
Molecular function	• protein kinase inhibitor activity • transporter activity • calcium ion binding • protein binding • microtubule binding • potassium channel regulator activity • kinase binding • calcium-dependent protein binding
Cellular component	• Golgi membrane • nucleus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum-Golgi intermediate compartment • cytosol • plasma membrane • microtubule cytoskeleton • transport vesicle
Biological process	• microtubule bundle formation • negative regulation of protein phosphorylation • negative regulation of protein kinase activity • protein export from nucleus • potassium ion transport • small GTPase mediated signal transduction • negative regulation of phosphatase activity • calcium ion-dependent exocytosis • membrane docking • cytoplasmic microtubule organization • negative regulation of protein ubiquitination • negative regulation of protein autophosphorylation • negative regulation of NF-kappaB transcription factor activity • positive regulation of sodium:hydrogen antiporter activity • negative regulation of protein import into nucleus • transcytosis • protein stabilization • positive regulation of protein transport • regulation of intracellular pH • positive regulation of protein glycosylation • membrane organization • membrane fusion • negative regulation of calcineurin-NFAT signaling cascade • cellular response to acidity • positive regulation of protein targeting to membrane
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 11261 56398 Ensembl ENSG00000187446 ENSMUSG00000014077 UniProt Q99653 P61022 RefSeq (mRNA) NM_007236 NM_019769 RefSeq (protein) NP_009167 NP_062743 Location (UCSC) Chr 15:
41.52 – 41.57 Mb Chr 2:
119.55 – 119.59 Mb PubMed search

Calcium binding protein P22, also known as CHP, is a human gene.

The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.