Symptoms
- itchiness (pruritus). Pruritus is the primary symptom of cholestasis and is thought to be due to interactions of serum bile acids with opioidergic nerves. In fact, the mixed opioid agonist/antagonist Naltrexone is used to treat pruritus due to cholestasis.
- jaundice. Jaundice is an uncommon occurrence in intrahepatic cholestasis, but is common in obstructive cholestasis.
- pale stool. This symptom implies obstructive cholestasis.
- dark urine
Bile is secreted by the liver to aid in the digestion of fats. Drugs such as gold salts, nitrofurantoin, anabolic steroids, chlorpromazine, prochlorperazine, sulindac, cimetidine, erythromycin, and estrogen can cause cholestasis and may result in damage to the liver.
Read more about this topic: Cholestasis
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