Chiral pool synthesis is a strategy that aims to improve the efficiency of chiral synthesis. It starts the organic synthesis of a complex enantiopure chemical compound from a stock of readily available enantiopure substances. Common chiral starting materials include monosaccharides and amino acids. The built-in chirality is then preserved in the remainder of the reaction sequence.
This strategy is especially helpful if the desired molecule bears a great resemblance to cheap enantiopure natural products. Otherwise, a long, tortuous synthesis involving many steps with attendant losses in yield may be required. At times, it may be difficult to find a suitable enantiopure starting material; other techniques may prove more fruitful.
General methods used in chiral pool synthesis are the use of protecting groups, and functional group interconversion (FGI).
Read more about Chiral Pool Synthesis: Examples, Enantiomeric Scaffolding
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