The Chemin de Fer du Midi, often abbreviated to CF du Midi, was an early French railway company.
In 1934 it merged with the Chemin de Fer de Paris à Orléans to become part of the Chemin de Fer de Paris à Orléans et du Midi (PO-Midi).
In 1856, the Chemin de Fer du Midi completed its rail line from Bordeaux to Toulouse. In 1857, it continued on from Toulouse through Narbonne to Sète. This put it in competition with the Canal du Midi. In 1858, the Canal du Midi was leased to the railroad on 28 May 1858.