| Gene Ontology | |
|---|---|
| Molecular function | • protein serine/threonine kinase activity • protein binding • ATP binding • histone kinase activity (H3-T11 specific) |
| Cellular component | • chromosome, telomeric region • chromatin • condensed nuclear chromosome • nucleus • nucleoplasm • replication fork • centrosome • cytosol |
| Biological process | • cell cycle checkpoint • DNA damage checkpoint • G2/M transition of mitotic cell cycle • DNA replication • DNA repair • response to DNA damage stimulus • DNA damage induced protein phosphorylation • regulation of double-strand break repair via homologous recombination • regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage • peptidyl-threonine phosphorylation • G2/M transition DNA damage checkpoint • regulation of S phase • negative regulation of mitosis • regulation of mitotic centrosome separation • chromatin-mediated maintenance of transcription • cellular response to mechanical stimulus • cellular response to caffeine • replicative senescence • regulation of histone H3-K9 acetylation |
| Sources: Amigo / QuickGO | |
125.5 – 125.55 Mb
36.71 – 36.73 Mb
Serine/threonine-protein kinase Chk1 is an enzyme that in humans is encoded by the CHEK1 gene.
Chk1 is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis.