In Entertainment
- Challenger (1990 film), about the space shuttle Challenger disaster
- The Challengers, a 1990 film produced for the Canadian Broadcasting Corporation
- Challenger (comics), a Marvel Comics Golden Age superhero
- Challenger (video game), developed by Hudson Soft
- Challenger (game show), a 1997 Australian game show
- Challengers of the Unknown a team of costumed crime fighters from DC Comics
- Challenger (Star Trek), a Star Trek: New Earth novel
- Challengers (album), by The New Pornographers
- The Challengers (band), a 1960s surf rock group
- The Challengers (game show), a 1990 American game show hosted by Dick Clark
- Challengers (manga), the shōnen-ai manga by Hinako Takanaga
- Professor Challenger, a fictional scientist and adventurer created by Arthur Conan Doyle
- "Challenger", a song by Misia from Mars & Roses
- Challenger (Knut album), by Knut
- Challenger (Memphis May Fire album), by Memphis May Fire
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