Production
Production of CRMs is split into two categories: Calibrants and matrix CRMs. Calibrants are pure standards used for calibrating instruments. These are usually produced by commercial producers (Merck KGaA, Sigma Aldrich, Biopure, Chem-Lab, NSI Solutions and SPEX CertiPrep) and companies that specialize in CRMs. Matrix CRMs contain an analyte in a sample (e.g. lead in fish). Due to the difficulty in its production and value assignment, these are usually produced by national or transnational metrology institutes like NIST (USA), BAM (Germany), KRISS (Korea) and JRC-IRMM (Joint Research Centre European Commission).
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