Cerebral perfusion pressure, or CPP, is the net pressure gradient causing cerebral blood flow to the brain (brain perfusion). It must be maintained within narrow limits because too little pressure could cause brain tissue to become ischemic (having inadequate blood flow), and too much could raise intracranial pressure (ICP).
Read more about Cerebral Perfusion Pressure: Autoregulation
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“Destiny is an absolutely definite and inexorable ruler. Physical ability and moral determination count for nothing. It is impossible to perform the simplest act when the gods say “no.” I have no idea how they bring pressure to bear on such occasions; I only know that it is irresistible.”
—Aleister Crowley (1875–1947)