CD46

CD46

Identifiers Symbols CD46; AHUS2; MCP; MIC10; TLX; TRA2.10 External IDs OMIM: 120920 MGI: 1203290 HomoloGene: 7832 GeneCards: CD46 Gene

Gene Ontology
Molecular function	• complement binding • endopeptidase activity • enzyme inhibitor activity • receptor activity
Cellular component	• inner acrosomal membrane • Golgi apparatus • plasma membrane • integral to plasma membrane • cell surface • basolateral plasma membrane
Biological process	• proteolysis • complement activation, classical pathway • single fertilization • virus-host interaction • regulation of complement activation • innate immune response • negative regulation of complement activation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4179 17221 Ensembl ENSG00000117335 ENSMUSG00000016493 UniProt P15529 O88174 RefSeq (mRNA) NM_002389.4 NM_010778.3 RefSeq (protein) NP_002380.3 NP_034908.1 Location (UCSC) Chr 1:
207.93 – 207.97 Mb Chr 1:
195.04 – 195.09 Mb PubMed search

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.