Function
The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. However little is known about its exact function.
CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell. Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell adhesion, or to facilitate opening of vascular lumens. Regardless of their mode of action, under all circumstances CD34 and its relatives, podocalyxin and endoglycan, have been shown to facilitate cell migration.
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