CCL3
| Gene Ontology | |
|---|---|
| Molecular function | • protein kinase activity • calcium-dependent protein kinase C activity • protein binding • chemokine activity • phospholipase activator activity • kinase activity • CCR1 chemokine receptor binding • CCR5 chemokine receptor binding • chemoattractant activity |
| Cellular component | • extracellular region • extracellular space • intracellular • cytoplasm • cytosol |
| Biological process | • MAPK cascade • osteoblast differentiation • cell activation • monocyte chemotaxis • protein phosphorylation • calcium ion transport • cellular calcium ion homeostasis • exocytosis • chemotaxis • inflammatory response • cytoskeleton organization • cell-cell signaling • behavior • regulation of cell shape • response to toxin • positive regulation of gene expression • negative regulation of gene expression • T cell chemotaxis • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • phosphorylation • calcium-mediated signaling • signaling • positive regulation of cell migration • negative regulation of bone mineralization • neutrophil chemotaxis • lipopolysaccharide-mediated signaling pathway • positive regulation of tumor necrosis factor production • eosinophil degranulation • protein kinase B signaling cascade • positive regulation of neuron apoptotic process • astrocyte cell migration • negative regulation by host of viral transcription • negative regulation of osteoclast differentiation • eosinophil chemotaxis • macrophage chemotaxis • lymphocyte chemotaxis • positive regulation of interleukin-1 beta secretion • positive regulation of inflammatory response • positive regulation of calcium-mediated signaling • positive chemotaxis • positive regulation of protein kinase B signaling cascade • positive regulation of calcium ion transport • regulation of sensory perception of pain • positive regulation of ERK1 and ERK2 cascade • response to cholesterol • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to organic cyclic compound • granulocyte chemotaxis • positive regulation of natural killer cell chemotaxis |
| Sources: Amigo / QuickGO | |
34.42 – 34.42 Mb
Chemokine (C-C motif) ligand 3 (CCL3) is a protein that in humans is encoded by the CCL3 gene.
CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.
Read more about CCL3: Interactions