Catechol-O-methyl Transferase
| Gene Ontology | |
|---|---|
| Molecular function | • magnesium ion binding • O-methyltransferase activity • catechol O-methyltransferase activity |
| Cellular component | • mitochondrion • cytosol • plasma membrane • integral to membrane • intracellular membrane-bounded organelle |
| Biological process | • xenobiotic metabolic process • synaptic transmission • female pregnancy • learning • estrogen metabolic process • response to organic cyclic compound • methylation • response to lipopolysaccharide • neurotransmitter catabolic process • neurotransmitter biosynthetic process • dopamine catabolic process • response to drug • small molecule metabolic process • negative regulation of dopamine metabolic process • response to pain • multicellular organismal reproductive process • negative regulation of smooth muscle cell proliferation • positive regulation of homocysteine metabolic process |
| Sources: Amigo / QuickGO | |
19.93 – 19.96 Mb
18.41 – 18.43 Mb
| catechol-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.6 | ||||||||
| CAS number | 9012-25-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | |||||||||
| Gene Ontology | |||||||||
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957. Read more about Catechol-O-methyl Transferase: Function, Genetics in Humans, Nomenclature, COMT Inhibitors Related Phrases
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