Side Effects
Compared to amphotericin B, caspofungin seems to have a relatively low incidence of side effects. In clinical studies and postmarketing reports, the side effects seen in 1% or more of the patients were as follows:
- Gastrointestinal system: nausea, vomiting, abdominal pain, and diarrhea
- Central nervous system: headache
- Whole body: fever, phlebitis or thrombophlebitis, complications at the intravenous cannulation site (e.g. induration), unspecified pain, flu-like syndrome, myalgia, chills, and paresthesia
- Respiratory: dyspnea
- Renal: increased plasma creatinine
- Hematological: anemia
- Electrolytes: hypokalemia
- Liver: increased liver enzymes (asymptomatic)
- Hypersensitivity: rash, facial edema, pruritus
- Other: tachycardia
Additionally, infrequent cases of symptomatic liver damage, peripheral edema and swelling, and hypercalcemia have been seen. One case of anaphylaxis (severe allergic reaction) has also been noted.
Read more about this topic: Caspofungin
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