The Casein kinase 2 (EC 2.7.11.1) is a serine/threonine-selective protein kinase that is a tetramer of two alpha subunits and two beta subunits. The alpha subunits have the catalytic kinase domain. Casein kinase 2 has been implicated in cell cycle control, DNA repair, regulation of the circadian rhythm and other cellular processes.
Casein kinase 2 activity has been reported to be activated following Wnt signaling pathway activation. A Pertussis toxin-sensitive G protein and Dishevelled appear to be an intermediary between Wnt-mediated activation of the Frizzled receptor and activation of casein kinase 2.
Mice that lack casein kinase 2 alpha prime have a defect in the morphology of developing sperm.
casein kinase 2,
alpha 1 polypeptide |
Identifiers |
Symbol |
CSNK2A1 |
Entrez |
1457 |
HUGO |
2457 |
OMIM |
115440 |
RefSeq |
NM_001895 |
UniProt |
P68400 |
Other data |
EC number |
2.7.11.1 |
Locus |
Chr. 20 p13 |
|
casein kinase 2,
alpha prime polypeptide |
Identifiers |
Symbol |
CSNK2A2 |
Entrez |
1459 |
HUGO |
2459 |
OMIM |
115442 |
RefSeq |
NM_001896 |
UniProt |
P19784 |
Other data |
EC number |
2.7.11.1 |
Locus |
Chr. 16 |
|
casein kinase 2,
beta polypeptide |
Identifiers |
Symbol |
CSNK2B |
Entrez |
1460 |
HUGO |
2460 |
OMIM |
115441 |
RefSeq |
NM_001320 |
UniProt |
P67870 |
Other data |
EC number |
2.7.11.1 |
Locus |
Chr. 6 p21.3 |
|