Carlisle is a surname, and may refer to:
- Anthony Carlisle, surgeon and discover of electrolysis
- Belinda Carlisle, American singer, of the Go-Go's
- Bob Carlisle, American Christian singer
- Clarke Carlisle, English footballer
- Cooper Carlisle, American Football player with the Oakland Raiders
- Elsie Carlisle, English singer, popular in the 1920s and 1930s
- Geno Carlisle, American basketball player
- James Carlisle, former Governor-General of Antigua and Barbuda
- Jodi Carlisle, American actress
- John Carlisle (disambiguation):
- John Griffin Carlisle, late 19th century Democratic Party politician in America
- John Russell Carlisle, British Conservative MP
- John Carlisle (actor), British television and stage actor
- Kenneth Carlisle, British Conservative MP
- Kitty Carlisle, American singer, actress and spokeswoman for the arts
- Lindsey Carlisle, South African field hockey player
- Mark Carlisle, British Conservative Cabinet member and MP
- Mary Carlisle, American actress and singer
- Michael Carlisle, British engineer and public servant
- Orville Carlisle, American inventor of model rocketry
- Peter Carlisle, the Prosecuting Attorney of Honolulu, Hawaii
- Rick Carlisle, American basketball player and coach
- Stuart Carlisle, Zimbabwean cricketer