Connection With Direct Serotonergic Agonist Drugs
Elevated prevalence of cardiac fibrosis and related valvopathies was found to be associated with use of a number of unrelated drugs following long-term statistical analysis once the drugs had been on the market for some time. The cause of this was unknown at the time, but eventually it was realised that all the implicated drugs acted as agonists at 5-HT2B receptors in the heart in addition to their intended sites of action elsewhere in the body. The precise mechanisms involved remain elusive however, as while the cardiotoxicity shows some dose-response relationship, it does not always develop, and consistent daily use over an extended period tends to be most strongly predictive of development of valvopathy. The drugs most classically associated with the condition are weight loss drugs such as fenfluramine and chlorphentermine, and anti-parkinsonian drugs such as pergolide and cabergoline, which are prescribed to be taken several times a day, often for months or years at a time. Drugs which act as 5-HT2B agonists but are used only intermittently are capable of producing the same kind of heart damage, but tend to be less likely to do so. Also while the heart valve changes can result in permanent damage and life-threatening heart problems if use of the causative drug is continued, longitudinal studies of former patients suggest that the damage will heal over time to some extent at least.
Read more about this topic: Cardiac Fibrosis
Famous quotes containing the words connection with, connection, direct and/or drugs:
“What is the vanity of the vainest man compared with the vanity which the most modest person possesses when, in connection with nature and the world, he experiences himself as “man”!”
—Friedrich Nietzsche (1844–1900)
“Much is made of the accelerating brutality of young people’s crimes, but rarely does our concern for dangerous children translate into concern for children in danger. We fail to make the connection between the use of force on children themselves, and violent antisocial behavior, or the connection between watching father batter mother and the child deducing a link between violence and masculinity.”
—Letty Cottin Pogrebin (20th century)
“As for your friend, my prospective reader, I hope he ignores Fort Sumter, and “Old Abe,” and all that; for that is just the most fatal, and, indeed, the only fatal weapon you can direct against evil ever; for, as long as you know of it, you are particeps criminis. What business have you, if you are an “angel of light,” to be pondering over the deeds of darkness, reading the New York Herald, and the like.”
—Henry David Thoreau (1817–1862)
“Razors pain you;
Rivers are damp;
Acids stain you;
And drugs cause cramp.
Guns aren’t lawful;
Nooses give;
Gas smells awful;
You might as well live.”
—Dorothy Parker (1893–1967)