Virology
The genome is 5.4-kilobbases in length. The termini are palindromic. There is a single P6 promoter which through the mechanism of alternative splicing and alternative polyadenylation two nonstructural proteins (NS1 and NP1) and two capsid proteins (VP1 and VP2) are transcribed. The NS1 protein is indispensable for genome replication. The NP1 protein, unique to the Bocavirus genus, appears to be critical for optimal viral replication, as the NP1 knockout mutant of MVC suffers from severe impairment of replication.
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