Structure
Calcineurin is a heterodimer of a 61-kD calmodulin-binding catalytic subunit, calcineurin A and a 19-kD Ca2+-binding regulatory subunit, calcineurin B. There are three isozymes of the catalytic subunit, each encoded by a separate gene (PPP3CA, PPP3CB, and PPP3CC) and two isoforms of the regulatory, also encoded by separate genes (PPP3R1, PPP3R2).
protein phosphatase 3, catalytic subunit, alpha isozyme |
Identifiers |
Symbol |
PPP3CA |
Alt. symbols |
CALN, CALNA |
Entrez |
5530 |
HUGO |
9314 |
OMIM |
114105 |
RefSeq |
NM_000944 |
UniProt |
Q08209 |
Other data |
EC number |
3.1.3.16 |
Locus |
Chr. 4 q24 |
|
protein phosphatase 3, catalytic subunit, beta isozyme |
Identifiers |
Symbol |
PPP3CB |
Alt. symbols |
CALNB |
Entrez |
5532 |
HUGO |
9315 |
OMIM |
114106 |
RefSeq |
NM_021132 |
UniProt |
P16298 |
Other data |
EC number |
3.1.3.16 |
Locus |
Chr. 10 q22.2 |
|
protein phosphatase 3, catalytic subunit, gamma isozyme |
Identifiers |
Symbol |
PPP3CC |
Entrez |
5533 |
HUGO |
9316 |
OMIM |
114107 |
RefSeq |
NM_005605 |
UniProt |
P48454 |
Other data |
EC number |
3.1.3.16 |
Locus |
Chr. 8 p21.3 |
|
protein phosphatase 3, regulatory subunit B, alpha |
Identifiers |
Symbol |
PPP3R1 |
Entrez |
5534 |
HUGO |
9317 |
OMIM |
601302 |
RefSeq |
NM_000945 |
UniProt |
P63098 |
Other data |
EC number |
3.1.3.16 |
Locus |
Chr. 2 p14 |
|
protein phosphatase 3, regulatory subunit B, beta |
Identifiers |
Symbol |
PPP3R2 |
Entrez |
5535 |
HUGO |
9318 |
OMIM |
613821 |
RefSeq |
NM_147180 |
UniProt |
Q96LZ3 |
Other data |
EC number |
3.1.3.16 |
Locus |
Chr. 9 q31 |
|