Cadiot-Chodkiewicz Coupling - Eglinton Reaction

In the related Eglinton reaction two terminal alkynes are coupled directly by a copper(II) salt such as cupric acetate.

The Eglinton Reaction has been used to synthesize a number of fungal antibiotics and is important for carbon-carbon bond formation via the oxidative coupling of alkynes.

This procedure was used in the synthesis of cyclooctadecanonaene. Another example is the synthesis of diphenyldiacetylene from phenylacetylene.

Read more about this topic:  Cadiot-Chodkiewicz Coupling

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