Cadiot-Chodkiewicz Coupling
The Cadiot–Chodkiewicz coupling in organic chemistry is a coupling reaction between a terminal alkyne and a haloalkyne catalyzed by a copper(I) salt such as copper(I) bromide and an amine base. The reaction product is a di-acetylene or di-alkyne.
The reaction mechanism involves deprotonation by base of the acetylenic proton followed by formation of a copper(I) acetylide. A cycle of oxidative addition and reductive elimination on the copper center then creates a new carbon-carbon bond.
Related couplings are the Glaser coupling and the Eglinton coupling.
Read more about Cadiot-Chodkiewicz Coupling: Cadiot-Chodkiewicz Coupling, Eglinton Reaction, Hay Coupling
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