Protein Structure
The BRCA1 protein contains the following domains:
- Zinc finger, C3HC4 type (RING finger)
- BRCA1 C Terminus (BRCT) domain
This protein also contains nuclear localization signal and nuclear export signal motifs.
The human BRCA1 protein consists of four major protein domains; the Znf C3HC4- RING domain, the BRCA1 serine domain and two BRCT domains. These domains encode approximately 27% of BRCA1 protein. There are six known isoforms of P38398 BRCA1, with isoforms 1 and 2 comprising 1863 amino acids each.
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