Further Improvement of Anticancer Potency
Laboratory studies and clinical trials are investigating whether it might be possible to further increase the anticancer potency of bortezomib by combining it with novel types of other pharmacologic agents. For example, clinical trials have indicated that the addition of thalidomide, lenalidomide, inhibitors of vascular endothelial growth factor (VEGF), or arsenic trioxide might be beneficial. In laboratory studies, it was found that bortezomib killed multiple myeloma cells more efficiently when combined, for example, with histone deacetylase inhibitors, thapsigargin, or celecoxib. However, the therapeutic efficacy and safety of any of these latter combinations has not yet been evaluated in cancer patients.
Read more about this topic: Bortezomib
Famous quotes containing the words improvement and/or potency:
“The American people owe it to themselves, and to the cause of free Government, to prove by their establishments for the advancement and diffusion of knowledge, that their political Institutions ... are as favorable to the intellectual and moral improvement of Man as they are conformable to his individual and social rights.”
—James Madison (1751–1836)
“The horse, the horse! The symbol of surging potency and power of movement, of action, in man.”
—D.H. (David Herbert)